Sean O'Brien Strub (born May 16, 1958) is an American writer, activist, elected official, historic preservationist and documentary filmmaker.

Sean Strub is a 40+ year HIV survivor and longtime LGBT and HIV activist. He was active with the People With AIDS Coalition/NY in the mid 80s, chaired ACT UP/New York’s fundraising committee in the late 80s, was the first openly HIV-positive person to run for federal office (1990), produced the Obie Award-winning hit Off-Broadway play, The Night Larry Kramer Kissed Me (1992) and founded POZ Magazine in 1994. Today he is executive director of The Sero Project, a U.S.-based network of people living with HIV combating HIV criminalization, as well as having served as Mayor of Milford, Pennsylvania.