When a mysterious biological threat arises in the Amazon Rainforest, a brilliant scientist must grapple with her own mental health to help save humanity.

In 2028, using satellite data, scientists stumble upon a mysterious heat source hidden deep within the Amazon Rainforest. Reports surface of Amazon Indigenous communities vanishing without a trace. At the same time stories emerge of deadly attacks by new species of insects, some capable of manipulating human behaviour.

Scarlett Silverman, a renowned systems ecologist, is invited to research what has become known as the Amazon Anomaly. While it’s the opportunity of a lifetime, solving this puzzle will exact a dire toll upon her.

As knowledge of the anomaly spreads and the threat rapidly approaches the city of Manaus, radical environmental groups claim the phenomenon is nature's revolt against destructive environmental practices. Amidst growing global unrest, a small group of scientists races against time to understand and stop the Anomaly, while the fate of the world hangs in the balance.